Farmakologik xususiyatlari
Kyurazit (azitromitsin) makrolid antibiotiklar – azalidlar guruhiga mansub. Preparat keng ta’sir doirasiga ega. Azitromitsinning ta’sir mexanizmi – bakteriyalarda oqsil sintezini 50S-ribosomal subbirlik bilan bog‘lanish orqali inhibitsiya qilishdir. Azitromitsin keng doiradagi gram-musbat va gram-manfiy bakteriyalarga nisbatan faol Gram-musbat kokklar Streptococcus pneumoniae, Streptococcus pyogenes (A guruhi β-gemolitik streptokokklar), Staphylococcus aureus, Staphylococcus epidermidis. Gram-musbat tayoqchalar Clostridium perfringens (eritromitsinga nisbatan faolroq); Corynebacterium diphtheriae; Listeria monocytogenes; Bacillus anthracis, Propionobacterium acnes, Nocardia spp. (ba’zi shtammlar). Gram-manfiy mikroorganizmlar Legionella pneumophila, Campylobacter jejuni va Bordetella pertussis, Haemophilus influenzae (eritromitsin va klaritromitsinga nisbatan faolroq), Haemophilus ducrei, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Borrelia spp., ba’zi Brucella spp. shtammlari, Flavobacterium spp. Escherichia coli, Salmonella spp. (S. enterica), Shigella spp. va Aeromonas spp., Bacteroides fragilisning ko‘pchilik shtammlari. Mikoplazmalar Mycoplasma pneumoniae va hominis, Ureaplasma urealyticum; Chlamydia trachomatis, C. pneumoniae spiroxetalar (Treponema pallidum); Ba’zi gram-manfiy anaeroblar, ba’zi Actinomyces spp. shtammlari, Mycobacterium scrofulaceum va M. kansasii. Eritromitsinga chidamli stafilokokklar, enterokokklar va streptokokklarning ko‘pchilik shtammlari, metitsillinga chidamli S. aureus shtammlari azitromitsinga ham chidamli. Pseudomonas aeruginosa, ba’zi Klebsiella spp., Enterobacter spp., Citrobacter spp., Proteus spp., Providencia spp., Morganella spp., Serracia spp. azitromitsinga chidamli.