Farmakologik xususiyatlari
Kyurazit (azitromitsin) makrolid antibiotiklar guruhi – azalidlar vakili hisoblanadi. Preparat keng ta'sir doirasiga ega. Azitromitsinning ta'sir mexanizmi – bakteriyalarda oqsil sintezini 50S-ribosomal bo'linmasi bilan bog'lanish orqali ingibitsiyalash.
Azitromitsin keng doiradagi gram-musbat va gram-manfiy bakteriyalarga nisbatan faol.
Gram-musbat kokklar: Streptococcus pneumoniae, Streptococcus pyogenes (A guruhi β-gemolitik streptokokklar), Staphylococcus aureus, Staphylococcus epidermidis. Gram-musbat tayoqchalar: Clostridium perfringens (eritromitsinga nisbatan faolroq); Corynebacterium diphtheriae; Listeria monocytogenes; Bacillus anthracis, Propionobacterium acnes, Nocardia spp. (ba'zi shtammlar).
Gram-manfiy mikroorganizmlar: Legionella pneumophila, Campylobacter jejuni va Bordetella pertussis, Haemophilus influenzae (eritromitsin va klaritromitsinga nisbatan faolroq), Haemophilus ducrei, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Borrelia spp., ba'zi Brucella spp. shtammlari, Flavobacterium spp.
Escherichia coli ning ko'pchilik shtammlari, Salmonella spp. (S. enterica) turlari, Shigella spp. va Aeromonas spp., Bacteroides fragilis.
Mikoplazmalar: Mycoplasma pneumoniae va hominis, Ureaplasma urealyticum; Chlamydia trachomatis, C. pneumoniae; spiroxetalar (Treponema pallidum);
Ba'zi gram-manfiy anaeroblar, ba'zi Actinomyces spp. shtammlari, Mycobacterium scrofulaceum va M. kansasii.
Eritromitsinga chidamli stafilokokklar, enterokokklar va streptokokklarning ko'pchilik shtammlari, metitsillinga chidamli S. aureus shtammlari azitromitsinga ham chidamli. Pseudomonas aeruginosa, ba'zi Klebsiella spp., Enterobacter spp., Citrobacter spp., Proteus spp., Providencia spp., Morganella spp., Serracia spp. azitromitsinga chidamli.