Farmakologik xususiyatlari
Levofloksatsin - sintetik antibakterial preparat keng spektrli ta'sirga ega florokinolonlar guruhidan bo'lib, faol modda sifatida levofloksatsin - ofloksatsinning levovrashi isomerini o'z ichiga oladi. Levofloksatsin DNK-girazani bloklaydi, superspiralizatsiyani buzadi va DNKning uzilishlarini bog'laydi, DNK sintezini inhibe qiladi, sitoplazmada, hujayra devorida va membranalarda chuqur morfologik o'zgarishlarni keltirib chiqaradi.
Levofloksatsin ko'p mikroorganizmlar shtammlariga nisbatan in vitro va in vivo sharoitlarda faol.
Aerob gram ijobiy mikroorganizmlar: Corynebacterium diphtheriae, Enterococcus faecalis, Enterococcus spp, Listeria monocytogenes, Staphylococcus koagulaza-negativ methi-S(I), Staphylococcus aureus methi-S, Staphylococcus epidermidis methi-S, Staphylococcus spp (CNS), Streptococci guruh C va G, Streptococcus agalactiae, Streptococcus pneumoniae peni I/S/R, Streptococcus pyogenes, Viridans streptococci peni-S/R.
Aerob gram manfiy mikroorganizmlar: Acinetobacter baumannil, Acinetobacter spp, Actinobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Enterobacter spp, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae ampi-S/R, Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella oxytoca, Klebsiella pneumoniae, Klebsiella spp, Moraxela catarrhalis β+/β-, Morganella morganii, Neisseria gonorrhoeae non PPNG/PPNG, Neisseria meningitidis, Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida, Pasteurella spp, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Providencia spp, Pseudomonas aeruginosa, Pseudomonas spp, Salmonella spp, Serratia marcescens, Serratia spp.
Anaerob mikroorganizmlar: Bacteroides fragilis, Bifidobacterium spp, Clostridium perfringens, Fusobacterium spp, Peptostreptococcus, Propionibacterum spp, Veilonella spp. Boshqa mikroorganizmlar: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp, Mycobacterium spp, Mycobacterium leprae, Mikobakterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae, Ricketsia spp, Ureaplasma urealyticum.