Himoya qatlami materiali: Namlikdan himoyalangan oq qatlam (IC -MS 218), titana dioksid, izopropil spirti, metilenxlorid.

Plyonka qoplama materiali: Yorug‘likdan himoyalovchi oq qatlam (IG- 001), izopropil spirti, metilenxlorid

Klinik sinovlarning yetarli emasligi va o‘sish davrida xinolonlarning bo‘g‘im xaftagasiga mumkin bo‘lgan zararli ta’siri sababli Tseleyo preparatini homiladorlik va laktatsiya davrida qo‘llash mumkin emas.

Tayinlashda ajratilgan qo‘zg‘atuvchilarning unga sezgirligini aniqlash lozim.

Doza kasallik og‘irligi, infeksiya turi, organizm holati, bemorning yoshi, vazni va buyrak funksiyasiga bog‘liq.

Dorini ovqat paytida yoki ovqatlar orasida, chaynalmay, yetarli miqdorda suyuqlik bilan ichish tavsiya etiladi.

Buyrak funksiyasi normal bo‘lgan kattalar uchun tavsiya etiladigan doza (kreatinin klirensi (KK) > 50 ml/min)

O‘tkir bakterial sinusitda – 500 mg 1 marta/kun davomida 10-14 kun.

Xronik bronxit zo‘rayishida – 250-500 mg 1 marta/kun davomida 7-10 kun.

Jamoada orttirilgan pnevmoniyada – 500 mg 1 yoki 2 marta/kun davomida 7-14 kun.

Murakkablanmagan siydik yo‘llari va buyrak infeksiyalarida – 250 mg (½ tabletka) 1 marta/kun davomida 3 kun.

Murakkab siydik yo‘llari infeksiyalarida – 250 mg (½ tabletka) 1 marta/kun davomida 7-10 kun.

Xronik bakterial prostatitda – 500 mg 1 marta/kun davomida 28 kun.

Terining va yumshoq to‘qimalarning infeksiyalarida – 250-500 mg 1-2 marta/kun davomida 7-14 kun.

Intraabdominal infeksiyalarda – 500 mg 1 marta/kun – 7-14 kun (anaerob floraga ta’sir qiluvchi antibakterial preparatlar bilan birga).

Sil (dori vositalariga chidamli shakllar kompleks terapiyasi) – 500 mg 1-2 marta/kun, davolash kursi 3 oygacha.

Levofloksasin - keng ta'sir doirasiga ega bo'lgan, ftorxinolonlar guruhiga mansub sintetik antibakterial preparat bo'lib, faol modda sifatida levofloksasin - ofloksasinning levorotatsion izomerini o'z ichiga oladi. Levofloksasin DNK-girazani bloklaydi, DNKning superspiralizatsiyasi va uzilishlarining tiklanishini buzadi, DNK sintezini ingibitsiya qiladi, bakteriyalarning sitoplazmasi, hujayra devori va membranalarida chuqur morfologik o'zgarishlarni chaqiradi. Levofloksasin ko'pgina mikroorganizmlar shtammlariga nisbatan in vitro va in vivo sharoitlarda faol.

Sezgir mikroorganizmlar (MPK <2 mg/l):

Aerob gram-musbat mikroorganizmlar: Corynebacterium diphtheria, Enterococcus spp. (jumladan, Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp., koagulaza-manfiy metitsillin sezgir - o'rtacha sezgir (jumladan, Staphylococcus aureus metitsillin sezgir, Staphylococcus epidermidis metitsillin sezgir), Streptococcus spp. (C va G guruhlari), Streptococcus agalactiae, Streptococcus pneumoniae penitsillin sezgir/-o'rtacha sezgir/-rezistent, Streptococcus pyogenes, Streptococcus spp. viridans guruhi penitsillin sezgir - rezistent.

Aerob gram-manfiy mikroorganizmlar: Acinetobacter spp. (jumladan, Acinetobacter baumanii), Citrobacter freundii, Eikenella corrodens, Enterobacter spp. (jumladan, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae ampisillin sezgir - rezistent, Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (jumladan, Klebsiella pneumoniae, Klebsiella oxytoca), Moraxella catarrhalis (beta-laktamaza ishlab chiqaruvchi va ishlab chiqarmaydigan shtammlar), Morganella morganii, Neisseria gonorrhoeae (jumladan, penitsillinaza ishlab chiqaruvchi), Neisseria meningitidis, Pasteurella spp. (jumladan, Pasteurella multocida, Pasteurella dagmatis, Pasteurella canis), Proteus mirabilis, Proteus vulgaris, Providencia spp. (jumladan, Providencia stuartii, Providencia rettgeri), Pseudomonas spp. (jumladan, Pseudomonas aeruginosa), Salmonella spp., Serratia spp. (jumladan, Serratia marcescens).

Anaerob mikroorganizmlar: Bacteroides fragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp., Peptostreptococcus, Propionibacterum spp., Veilonella spp. Boshqa mikroorganizmlar: Bartonella spp., Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (jumladan, Legionella pneumophila), Mycobacterium spp. (jumladan, Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsiae spp., Ureaplasma urealyticum.

O'rtacha sezgir (MPK>4 mg/l):

Aerob gram-musbat mikroorganizmlar: Corynebacterium urealyticum, Corynebacterium xerosis, Enterococcus faecium, Staphylococcus epidermidis

metitsillinrezistent, Staphylococcus haemolyticus metitsillinrezistent. Aerob gram-manfiy mikroorganizmlar: Burkholderia cepacia, Campilobacter jejuni, Campilobacter coli.

Anaerob mikroorganizmlar: Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus, Prevotella spp., Porphyromonas spp.

Barqaror (MPK >8 mg/l):

Aerob gram-musbat mikroorganizmlar: Corynebacterium jeikeium, Staphylococcus aureus metitsillinrezistent, boshqa Staphylococcus spp. koagulaza-manfiy metitsillinrezistent.

Aerob gram-manfiy mikroorganizmlar: Alcaligenes xylosoxidans.

Boshqa mikroorganizmlar: Mycobacterium avium.